Transcriptional and epigenetic control of mammalian cardiovascular development and function
Current studies focus on the identification of cell growth and differentiation signals that
modulate the transcriptional activities of myocardin family of transcription factors.
We are also investigating how pathophysiological signals, such as cardiac hypertrophy
and congenital heart failure, mediate change in myocardin-dependent cardiac gene expression.
In addition, we study how epigenetic factors, which modify chromatin, impact cardiac transcription
factors and cardiac gene expression during cardiovascular development.
miRNAs in cardiac muscle development and function