miRNAs in cardiac muscle development and function
To date, more than 700 human miRNAs have been identified. It has been estimated that at least 1% of the transcripts in the genome code for miRNAs, and that approximately 50% of all human genes are targets of miRNA regulation. However, the molecular mechanisms and the in vivo functions of most miRNAs remain unknown.
The long-term goal of our research is to understand the molecular mechanisms in which miRNAs control the proliferation and differentiation of cardiac muscle. We are currently investigating the in vivo function of miRNAs in cardiac muscle using both gain- and loss-of-function approaches via transgenic and gene knockout technologies.
miRNAs in skeletal muscle stem cell and regeneration